Main Article Content

Abstract

Introduction: The COVID-19 pandemic that occurred in 2019 most severely affected the older population and those with underlying diseases, these being risk factors for mortality. Circumstances present in renal patients on dialysis, so it is important to know what the impact of COVID-19 was on this population group.
Objective: To understand and synthesise the existing scientific evidence on the clinical characteristics of COVID-19 disease in patients with chronic kidney disease on dialysis.
Material and Method: A systematic review was carried out based on the PRISMA statement, in which 23 articles from the PubMed and Scopus databases were analysed. Original articles in English and Spanish that excluded the paediatric population were included.
Results: 23 articles of observational design were included. Mainly the results focused on incidence, clinical characteristics, such as symptomatology or evolution, mortality and preventive measures in dialysis units.
Conclusions: The incidence of COVID-19 was higher in dialysis units than in patients receiving home dialysis. The mildest symptomatology was common to the general population. In the most severe cases, about 50% of patients required hospitalisation and/or admission to an Intensive Care Unit. Mortality was quite high and was related to advanced age, comorbidity, male sex or clinical frailty. In addition, disease prevention measures were implemented in the dialysis units, as they are closed physical spaces where many patients are concentrated.

Keywords

COVID-19 renal dialysis hemodialysis peritoneal dialysis

Article Details

How to Cite
1.
Parra-Martos L, Cobacho-Salmoral O, Martínez-Urbano J, Crespo-Montero R. COVID-19 in the dialysis patient. A systematic review. Enferm Nefrol [Internet]. 2021 [cited 2025 Jun 15];24(4):[about 13 p.]. Available from: https://www.enfermerianefrologica.com/revista/article/view/4447

References

  1. Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al. A Novel Coronavirus from Patients with Pneumonia in China, 2019. N Engl J Med. 2020;382:727-33. DOI: https://doi.org/10.1056/NEJMoa2001017
  2. Lu R, Zhao X, Li J, Niu P, Yang B, Wu H, et al. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet. 2020;395(10224):565-74. DOI: https://doi.org/10.1016/S0140-6736(20)30251-8
  3. COVID-19: Events as they happen. WHO (World Health Organization). [Consultado 2 Mar 2021]. Disponible en: https://www.who.int/emergencies/diseases/novel-coronavirus-2019/events-as-they-happen.
  4. Coronaviridae Study Group of the International Committee on Taxonomy of Viruses. The species severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2. Nat Microbiol. 2020;5:536-44. DOI: https://doi.org/10.1038/s41564-020-0695-z
  5. Feng Z, Li Q, Zhang Y, Wu Z, Dong X, Ma H, et al. The epidemiological characteristics of an outbreak of 2019 Novel Coronavirus Diseases (COVID-19)-China, 2020. CCDC Weekly. 2020;2(8):113-22. DOI: https://doi.org/10.46234/ccdcw2020.032
  6. Guan W, Ni Z, Hu Y, Liang W, Ou C, He J, et al. Clinical Characteristics of Coronavirus Disease 2019 in China. N Engl J Med. 2020;382(18):1708-20. DOI: https://doi.org/10.1056/NEJMoa2002032
  7. Zheng Y, Xu H, Yang M, Zeng Y, Chen H, Liu R, et al. Epidemiological characteristics and clinical features of 32 critical and 67 noncritical cases of COVID-19 in Chengdu. J Clin Virol. 2020;127. DOI: https://doi.org/10.1016/j.jcv.2020.104366
  8. Eknoyan G, Lameire N, Barsoum R, Eckardt K, Levin A, Levin N, et al. The burden of kidney disease: improving global outcomes. Kidney Int. 2004;66:1310-4. DOI: https://doi.org/10.1111/j.1523-1755.2004.00894.x
  9. Otero A, de FA, Gayoso P, García F. Prevalence of chronic renal disease in Spain: results of the EPIRCE study. Nefrología. 2010;30(1):78-86.
  10. Kidney Diseases: Improving Clinical Outcomes (KDIGO) CKD Work Group. KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease. Kidney Int Suppl. 2013;3:1-150. Disponible en: https://kdigo.org/wp-content/uploads/2017/02/KDIGO_2012_CKD_GL.pdf.
  11. National Institute of Diabetes and Digestive and Kidney Diseases. Health Information: Insuficiencia Renal. [consultado 04 Mar 2021]. Disponible en: https://www.niddk.nih.gov/health-information/informacion-de-la-salud/enfermedades-rinones/insuficiencia-renal.
  12. Registro Español de Enfermos Renales (REER). Informe de diálisis y trasplante 2019. [consultado 06 Abr 2021]. Disponible en: https://www.senefro.org/contents/webstructure/INFORME_REER_SEN_2020_WEB_SEN.pdf.
  13. Gutiérrez D, Leiva-Santos J, Macías MJ, Cuesta A. Perfil sintomático de los pacientes con Enfermedad Renal Crónica Estadio 4 y 5. Enferm Nefrol. 2017;20(3):259-66. DOI: https://doi.org/10.4321/S2254-28842017000300010
  14. Urrutia G, Bonfill X. Declaración PRISMA: una propuesta para mejorar la publicación de revisiones sistemáticas y metaanálisis. Med Clin. 2010;135(11):507-11. DOI: https://doi.org/10.1016/j.medcli.2010.01.015
  15. Vandenbroucke J, Von E, Altman D, Gøtzsche P, Mulrow C, Pocock S, et al. Mejorar la comunicación de estudios observacionales en epidemiología (STROBE): explicación y elaboración. Gac Sanit. 2009;23(2):1-28. DOI: https://doi.org/10.1016/j.gaceta.2008.12.001
  16. Scimago Journal & Country Rank. [consultado May 2021]. Disponible en: https://www.scimagojr.com/.
  17. Anoun M, Khalil R, Mahfoud W, Fatfat H, Khalil L, Alameddine R, et al. Age and multimorbidities as por prognostic factors for COVID-19 in hemodialysis: a Lebanese national study. BMC Nephrol. 2021;22(73). DOI: https://doi.org/10.1186/s12882-021-02270-9
  18. Alberici F, Delbarba E, Manenti C, Econimo L, Valerio F, Pola A, et al. A report from the Brescia Renal COVID Task Force on the clinical characteristics and short-term outcome of hemodialysis patients with SARS-CoV-2 infection. Kidney Int. 2020;98:20-6. DOI: https://doi.org/10.1016/j.kint.2020.04.030
  19. Xiong F, Tang H, Liu L, Tu C, Tian J, Lei C, et al. Clinical Characteristics of and Medical Interventions for COVID-19 in Hemodialysis Patients in Wuhan, China. J Am Soc Nephrol. 2020;31:1387-97. DOI: https://doi.org/10.1681/ASN.2020030354
  20. Hsu C, Weiner D, Aweh G, Miskulin D, Manley H, Stewart C, et al. COVID-19 Among US Dialysis Patients: Risk Factors and Outcomes from a National Dialysis Provider. Am J Kidney Dis. 2021;77(5):748-56. DOI: https://doi.org/10.1053/j.ajkd.2021.01.003
  21. Lano G, Braconnier A, Bataille S, Cavaille G, Moussi-Frances J, Gondouin B, et al. Risk factors for severity of COVID-19 in chronic dialysis patients from a multicentre French cohort. Clin Kid J. 2020;13(4): 878-88. DOI: https://doi.org/10.1093/ckj/sfaa199
  22. Jager K, Kramer A, Chesnaye N, Couchoud C, Sánchez-Álvarez J, Garneata L, et al. Results from the ERA-EDTA Registry indicate a high mortality due to COVID-19 in dialysis patients and kidney transplant recipients across Europe. Kidney Int. 2020;98:1540-8. DOI: https://doi.org/10.1016/j.kint.2020.09.006
  23. Taji L, Thomas D, Oliver M, Ip J, Tang Y, Yeung A, et al. COVID-19 un patients undergoing long-term dialysis in Ontario. Can Med Assoc J. 2021;193(8):278-84. DOI: https://doi.org/10.1503/cmaj.202601
  24. Turgutalp K, Ozturk S, Arici M, Eren N, Gorgulu N, Islam M, et al. Determinants of mortality in a large group of hemodialysis patients hospitalized for COVID-19. BMC Nephrol. 2021;22(29). DOI: https://doi.org/10.1186/s12882-021-02233-0
  25. Couchoud C, Bayer F, Ayav C, Béchade C, Brunet F, Chantrel F, et al. Low incidence of SARS-CoV-2, risk factors of mortality and the course of illness in the French national cohort of dialysis patients. Kidney Int. 2020;98(6):1519-29. DOI: https://doi.org/10.1016/j.kint.2020.07.042
  26. Tomacruz DI, So PN, Pasilan RM, Camenforte JK, Duavit MI. Clinical Characteristics and Short-Term Outcomes of Chronic Dialysis Patients Admitted for COVID-19 in Metro Manila, Philippines. Int J Nephrol Renovasc Dis. 2021;14:41-51. DOI: https://doi.org/10.2147/IJNRD.S287455
  27. Min Y, Cheng L, Tu C, Li H, He D, Huang D, et al. Clinical characteristics of deceased hemodialysis patients affected by COVID‑19. Int Urol Nephrol. 2021;53:797-802. DOI: https://doi.org/10.1007/s11255-020-02700-x
  28. Kakkanattu TJ, Sankarasubbaiyan S, Yadav AK, Kundu M, Gowda N, Kumar V, et al. Outcome and Determinants of Outcome of COVID-19 Infection Among Hemodialysis Patients: Findings from a National Dialysis Network Program in India. Kidney Int Rep. 2021;6(5):1429-32. DOI: https://doi.org/10.1016/j.ekir.2021.03.003
  29. Corbett RW, Blakey S, Nitsch D, Loucaidou M, McLean A, Duncan N, et al. Epidemiology of COVID-19 in an Urban Dialysis Center. J Am Soc Nephrol. 2020;31(8):1815-23. DOI: https://doi.org/10.1681/ASN.2020040534
  30. Pizarro-Sánchez MS, Avello A, Mas-Fontao S, Stock da Cunha T, Goma-Garcés E, Pereira M, et al. Clinical Features of Asymptomatic SARS-CoV-2 Infection in Hemodialysis Patients. Kidney Blood Press Res. 2021;46:126-34. DOI: https://doi.org/10.1159/000512535
  31. Flythe JE, Assimon MM, Tugman MJ, Chang EH, Gupta S, Shah J, et al. Characteristics and Outcomes of Individuals with Pre-existing Kidney Disease and COVID-19 Admitted to Intensive Care Units in the United States. Am J Kidney Dis. 2020;77(2):190-203. DOI: https://doi.org/10.1053/j.ajkd.2020.09.003
  32. Kastali M, Kada AY, Ounnas S. Impact of COVID-19 infections on hemodialysis patients in the province of Blida, Argelia. Pan Afr Med J. 2020;31(1). [consultado 04 Abr 2021]. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7934889/pdf/PAMJ-SUPP-37-1-51.pdf. DOI: https://doi.org/10.11604/pamj.supp.2020.37.1.26850
  33. Hilbrands LB, Duivenvoorden R, Vart P, Franssen C, Hemmelder MH, Jager KJ, et al. COVID-19-related mortality in kidney transplant and dialysis patients: results of the ERACODA collaboration. Nephrol Dial Transplant. 2020;35(11):1973-83. DOI: https://doi.org/10.1093/ndt/gfaa261
  34. Zou R, Chen F, Chen D, Xu C, Xiong F. Clinical characteristics and outcome of hemodialysis patients with COVID-19: a large cohort study in a single Chinese center. Ren fail. 2020;42(1):950-7. DOI: https://doi.org/10.1080/0886022X.2020.1816179
  35. Valeri AM,Robbins-Juarez SY, Stevens JS, Ahn W, Rao MK, Radhakrishnan J, et al. Presentations and Outcomes of Patients with ESKD and COVID-19. J Am Soc Nephrol. 2020;31(7):1409-15. DOI: https://doi.org/10.1681/ASN.2020040470
  36. Seidel M, Hölzer B, Appel H, Babel N, Westhoff TH. Impact of renal disease and comorbidities on mortality in hemodialysis patients with COVID-19: a multicenter experience from Germany. J Nephrol. 2020;31:871-4. DOI: https://doi.org/10.1007/s40620-020-00828-8
  37. Roper T, Kumar N, Lewis-Morris T, Moxham V, Kassimatis T, Game D, et al. Delivering Dialysis During the COVID-19 Outbreak: Strategies and Outcomes. Kidney Int Rep. 2020;5(7):1090-4. DOI: https://doi.org/10.1016/j.ekir.2020.05.018
  38. Da Silva M, Abeygunaratne T, Alderson H, Ali I, Brown N, Chrysochou C, et al. Safely reducing hemodialysis frequency during the COVID-19 pandemic. BMC Nephrol. 2020;21(52). DOI: https://doi.org/10.1186/s12882-020-02172-2
  39. Apata IW, Cobb J, Navarrete J, Burkart J, Plantinga L, Lea JP. COVID-19 infection control measures and outcomes in urban dialysis centers in predominantly African American communities. BMC Nephrol. 2021;22(81). DOI: https://doi.org/10.1186/s12882-021-02281-6
  40. Maldonado M, Ossorio M, Del Peso G, Santos C, Álvarez L, Sánchez-Villanueva R, et al. Incidencia y resultados de la COVID-19 en una unidad de diálisis domiciliaria en Madrid (España) durante el pico de la pandemia. Nefrología. 2020;42(3):329-36. DOI: https://doi.org/10.1016/j.nefro.2020.09.002
  41. Albalate M, Arribas P, Torres E, Cintra M, Alcázar R, Puerta M, et al. Alta prevalencia de COVID-19 asintomático en hemodiálisis. Aprendiendo día a día el primer mes de pandemia de COVID-19. Nefrología. 2020;40 (3):279-86. DOI: https://doi.org/10.1016/j.nefro.2020.04.005
  42. Arenas MD, Villar J, González C, Cao H, Collado S, Crespo M, et al. Manejo de la epidemia por coronavirus SARS-CoV-2 (COVID-19) en unidades de hemodiálisis. Nefrología. 2020;40(2):258-64. DOI: https://doi.org/10.1016/j.nefro.2020.04.001
  43. Varatharaj A, Thomas N, Ellul M, Davies N, Pollak T, Tenorio E, et al. Neurological and neuropsychiatric complications of COVID-19 in 153 patients: a UK-wide surveillance study. Lancet. 2020;7(10):875-82. DOI: https://doi.org/10.2139/ssrn.3601761
  44. Nuzzo D, Picone P. Potential neurological effects of severe COVID-19 infection. Neurosci. Res. 2020;158:1-5. DOI: https://doi.org/10.1016/j.neures.2020.06.009
  45. Paules C, Marston H, Fauci A. Coronavirus Infections-More than just the Common Cold. JAMA. 2020;323(8):707-8. DOI: https://doi.org/10.1001/jama.2020.0757
  46. Ministerio de Sanidad. Actualización nº 367. Enfermedad por el coronavirus (COVID-19). Situación en España. [consultado 4 May 2021]. Disponible en: https://www.mscbs.gob.es/profesionales/saludPublica/ccayes/alertasActual/nCov/documentos/Actualizacion_367_COVID-19.pdf.
  47. Martos F, Luque J, Jiménez N, Mora E, Asencio C, García JM, et al. Comorbilidad y factores pronósticos al ingreso en una cohorte COVID-19 de un hospital general. Rev Clin Esp. 2020.
  48. Fried L, Tangen C, Walston J, Newman A, Hirsch C, Gottdiener J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol. 2001;56(3):146-56. DOI: https://doi.org/10.1093/gerona/56.3.M146
  49. Gutiérrez MF, Juárez OC. Obesidad y sexo masculino como factores de riesgo para casos moderados a severos de COVID-19. Rev Cienc Tecnol. 2021;17(1):19-23. DOI: https://doi.org/10.17268/rev.cyt.2021.01.02
  50. Ministerio de Sanidad. Recomendaciones para el manejo, prevención y control de COVID-19 en Unidades de Diálisis. [consultado 2 Abr 2021]. Disponible en: https://www.mscbs.gob.es/profesionales/saludPublica/ccayes/alertasActual/nCov/documentos/COVID19-hemodialisis.pdf.

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