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Abstract

Introduction: The Pan American Health Organization recognizes Chronic Kidney Disease of Nontraditional Causes as a serious form of kidney failure of uncertain etiology, which has reached devastating epidemic proportions in communities and saturation of health systems. Hypotheses related to infections, dehydration, global warming, hyperuricemia, exposure to are mentioned, however, these hypotheses have not been conclusive.
Objective: To carry out a systematic review on the relationship between non-traditional kidney disease and sociodemographic factors, agricultural exposure or heavy metals in the Latin American population.
Methodology: An integrative systematic review was carried out under the PRISMA guide in the Medigraphic, BioMed Central, Wiley Online Library, Web of Science, ScienceDirect, PubMed and Scopus databases. With the keywords: kidney disease, nephritis, heavy metals, agrochemicals, risk factor. Of which 39 studies were included after evaluating their methodological quality.
Results: it was found that 35.89% of the included studies had a high scientific rigor. Regarding the causes, it was found that exposure to agrochemicals was the most frequent cause of this disease.
Conclusion: Heavy metals and agrochemicals have been shown to influence the development of Chronic Kidney Disease of Nontraditional Causes, however, most of the results are not generals and doesn´t demonstrate a statistically significant relationship. Sociodemographic factors have been little studied and more rigorous scientific research on this variable is required.

Keywords

kidney diseases nephritis heavy metals agrochemicals risk factors

Article Details

How to Cite
1.
Ortega-Moctezuma O, Zárate-Pérez J, Alba-Alba CM, Jiménez-Hernández M, Ramírez-Girón N. Chronic Kidney Disease Associated with Heavy Metal Exposure and Agrochemicals in Latin America. Enferm Nefrol [Internet]. 2023 [cited 2025 Apr 30];26(2):[about 12 p.]. Available from: https://www.enfermerianefrologica.com/revista/article/view/4498

References

  1. Organización Panamericana de la Salud. Washington. [Internet] 2017 [consultado 10 Feb 2021]; Disponible en: https://iris.paho.org/handle/10665.2/34132.
  2. The GBD Collaborators. Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: A systematic analysis for the Global Burner Disease Study. 2015; 385(9963):117-71.
  3. Torres-Toledano, Marisol, Granados-García, Víctor y López-Ocañac, Luis Rafael Carga de la enfermedad renal crónica en México. Revista Médica del Instituto Mexicano del Seguro Social. [Internet] 2017;55(2):118-23. [consultado 28 Abr 2021]. Disponible en: https://www.redalyc.org/articulo.oa?id=457755436002.
  4. Campese VM. The unresolved epidemic of chronic kidney disease of uncertain origin (CKDu) around the world: A review and new insights. Clin Nephrol. [consultado 12 Feb 2021];95(2):65-80.
  5. Gifford FJ, Gifford RM, Eddleston M, Dhaun N. Endemic Nephropathy Around the World [Internet]. 2017 [consultado 10 Feb 2021]; 2: 282-92. Disponible en: https://www.kireports.org/article/S2468-0249(16)30168-1/abstract#%20.
  6. Wesseling C, Weiss I. Enfermedad renal crónica de etiología desconocida o de origen no tradicional: ¿una epidemia global? [Internet]. 2017 [consultado 15 Feb 2021]; 20 [200-02 p.]. Disponible en: https://archivosdeprevencion.eu/fasciculo.php?idrev=80.
  7. Redmon JH, Levine KE, Lebov J, Harrington J, Kondash AJ. A comparative review: Chronic Kidney Disease of unknown etiology (CKDu) research conducted in Latin America versus Asia. Environ Res [Internet]. 2021 Ene [consultado 15 Feb 2021]; 192:110270. Disponible: https://pubmed.ncbi.nlm.nih.gov/33035557/.
  8. Valcke M, Levasseur ME, Soares da Silva A, Wesseling C. Pesticide exposures and chronic kidney disease of unknown etiology: an epidemiologic review. Environ Health [Internet]. 2017 [consultado 15 Feb 2021]; 16:49.
  9. Orr SE, Bridges CC. Chronic kidney disease and exposure to nephrotoxic metals. Int. J. Mol. Sci. 2017 May; 18:1039.
  10. Wimalawansa SA, Wimalawansa SJ. Environmentally induced, occupational diseases with emphasis on chronic kidney disease of multifactorial origin affecting tropical countries. Ann Occup Environ Med [Internet]. 2016 [consultado 15 Feb 2021]; 5;28:33. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974668/.
  11. Vicente-Vicente L, et al. Nephrotoxicity of uranium: pathophysiological, diagnostic and therapeutic perspectives. Toxicol Sci [Internet]. 2010 [consultado 16 Feb 2021]; 118(2):324-47. Disponible en: https://pubmed.ncbi.nlm.nih.gov/20554698/.
  12. Ramos Vázquez J, Sánchez Orta Y. Salud, enfermedad renal y pobreza: un reto actual. Rev. Ciencias Médicas [Internet]. 2019 [consultado 16 Feb 2021]; 23:587-98. Disponible en: https://www.medigraphic.com/pdfs/pinar/rcm-2019/rcm194n.pdf.
  13. Briffa J, Sinagra E, Blundell R. Heavy metal pollution in the environment and their toxicological effects on humans Heliyon [Internet]. 2020 [consultado 16 Feb 2021]; 6(9):e04691. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32964150/.
  14. Rana MN, Tangpong J, Rahman MM. Toxicodynamics of Lead, Cadmium, Mercury and Arsenic- induced kidney toxicity and treatment strategy: A mini review. Toxicol Rep [Internet]. 2018 May [consultado 16 Feb 2021]; 26;5:704-13.
  15. Tsai HJ, Wu PY, Huang JC, Chen SC. Environmental Pollution and Chronic Kidney Disease. Int J Med Sci [Internet]. 2021 [consultado 17 Feb 2021]; 1;18(5):1121-29; Disponible en: https://pubmed.ncbi.nlm.nih.gov/33526971/.
  16. Fevrier-Paul A, Soyibo AK, Mitchell S, Voutchkov M. Role of Toxic Elements in Chronic Kidney Disease. J Health Pollut [Internet]. 2018 [consultado 17 Feb 2021]; 6;8(20):181202. Disponible en: https://pubmed.ncbi.nlm.nih.gov/30560001/.
  17. Sánchez Polo V, Garcia-Trabanino R, Rodriguez G, Madero M. Mesoamerican Nephropathy (MeN): What We Know so Far. Int J Nephrol Renovasc Dis [Internet]. 2020 [consultado 17 Feb 2021]; 2;13:261-72. Disponible en: https://pubmed.ncbi.nlm.nih.gov/33116757/.
  18. Ekong E, Jaar BG, Weaver VM. Lead-related nephrotoxicity: A review of the epidemiologic evidence. Kidney International [Internet]. 2006 [consultado 17 Feb 2021]; 70;2074-2084. Disponible en: https://pubmed.ncbi.nlm.nih.gov/17063179/.
  19. Silva LC, Ordúez P. La enfermedad renal crónica en las comunidades agrícolas de América Central: desafíos para epidemiología y salud pública. MEDICC Rev [Internet] 2018 [consultado 17 Feb 2021]; 16;66-71. Disponible en: https://mediccreview.org/wp-content/uploads/2018/04/mr_357_es.pdf.
  20. Almaguer M, Herrera R, Orantes CM. Chronic Kidney Disease of Unknown Etiology in Agricultural Communities. MEDICC Rev [Internet] 2014 [consultado 18 Feb 2021]; 16;9-15. Disponible en: https://www.medigraphic.com/pdfs/medicreview/mrw-2014/mrw142c.pdf.
  21. Herrera V, Almaguer L, Orantes N, López M, Brizuela D, Bayarre V, et al. Chronic interstitial nephritis of nontraditional causes in Salvadoran agricultural communities. Clin Nephrol [Internet]. 2020 [consultado 18 Feb 2021]; Supplement-Jan;93(1):S60-7. Disponible en: https://pubmed.ncbi.nlm.nih.gov/31699212/.
  22. Scammell MK, Sennett C, Laws R, Rubin R, Brooks D, Amador J, et al. Urinary Metals Concentrations and Biomarkers of Autoimmunity among Navajo and Nicaraguan Men. Int J Environ Res Public Health [Internet]. 2020 [consultado 18 Feb 2021]; 22;17(15):5263. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432079/. Disponible en: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0229413
  23. Dally M, Butler-Dawson J, Cruz A, Krisher L, Johnson R, Asensio C, et al. Longitudinal trends in renal function among first time sugarcane harvesters in Guatemala. PLoS One [Internet] 2020 Mar [consultado 18 Feb 2021]; 6;15(3):e0229413. Disponible en: https://pubmed.ncbi.nlm.nih.gov/29370016/.
  24. Butler-Dawson J, Krisher L, Asensio C, Cruz A, Tenney L, Weitzenkamp D, et al. Risk Factors for Declines in Kidney Function in Sugarcane Workers in Guatemala. J Occup Environ Med [Internet]. 2018 Jun [consultado 19 Feb 2021]; 60(6):548-58. Disponible en: https://pubmed.ncbi.nlm.nih.gov/29370016/.
  25. Rajapaksha H, Pandithavidana D, Dahanayake J. Demystifying Chronic Kidney Disease of Unknown Etiology (CKDu): Computational Interaction Analysis of Pesticides and Metabolites with Vital Renal Enzymes. Biomolecules [Internet] 2021 [consultado 19 Feb 2021] 10;11(2):261. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7916818/.
  26. VanDervor D, López D, Orantes-Navarro C, Rodríguez D. Spatial distribution of unspecified chronic kidney disease in El Salvador by crop area cultivated an ambient temperature. MEDICC Rev [Internet] 2014 Mayo [consultado 19 Feb 2021]; 16; 31-8. Dispponible en: https://www.academia.edu/84013421/Spatial_Distribution_of_Unspecified_Chronic_Kidney_Disease_in_El_Salvador_by_Crop_Area_Cultivated_and_Ambient_Temperature.
  27. Fischer R, Unrine J, Chandan V, Sanderson W, Mandayam S, Murray K, et al. Evidence of nickel and other trace elements and their relationship to clinical findings in acute Mesoamerican Nephropathy: A case-control analysis. PLoS One [Internet] 2020 [consultado 19 Feb 2021]; 10;15(11):e0240988. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0240988.
  28. Orantes N, Almaguer L, Alonso G, Díaz A, Hernández S, Herrera V, et al. The chronic kidney disease epidemic in el Salvador: the influence of agrochemicals. Rev. Cuba. Med. Tropical [Internet]. 2020 [consultado 19 Feb 2021]; 72; aprox. 1 p. Disponible en: http://www.revmedtropical.sld.cu/index.php/medtropical/article/view/531.
  29. López-Gálvez N, Wagoner R, Beamer P, de Zapien J, Rosales C. Migrant Farmworkers’ Exposure to Pesticides in Sonora, Mexico. Int J Environ Res Public Health [Internet]. 2018 [consultado 19 Feb 2021]; 26;15(12):2651. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313604/.
  30. Hutter H, Poteser M, Lemmerer K, Wallner P, Kundi M, Moshammer H, et al. Health Symptoms Related to Pesticide Use in Farmers and Laborers of Ecological and Conventional Banana Plantations in Ecuador. Int J Environ Res Public Health [Internet]. 2021 [consultado 19 Feb 2021]; 27;18(3):1126. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7908553/.
  31. Gouveia P, Rodriguez S, Carvalho N, Dos Santos Goncalves, Soares, D, Kelly R, et al. Nephrotoxic Effects Caused by Occupational Exposure to Agrochemicals in a Region of Northeastern Brazil: A Cross-Sectional Study. Environ Toxicol Chem [Internet]. 2021 [consultado 20 Feb 2021]; 40(4):1132-38. Disponible en: https://pubmed.ncbi.nlm.nih.gov/33315273/.
  32. Herrera R, Orantes CM, Almague M, Alfonso P, Bayarre HD, Leyva IM, et al. Características clínicas de la enfermedad renal crónica de causas no tradicionales en las comunidades agrícolas salvadoreñas. MEDICC Rev [Internet]. 2014 Abr [consultado 20 Feb 2021]; 16;1-21. Disponible en: https://www.medigraphic.com/pdfs/medicreview/mrw-2014/mrw142g.pdf.
  33. Sierra-Diaz E, Celis-de la Rosa A, Lozano-Kasten F, Trasande L, Peregrina-Lucano A, Sandoval-Pinto E, et al. Urinary Pesticide Levels in Children and Adolescents Residing in Two Agricultural Communities in Mexico. Int J Environ Res Public Health. 2019 Feb 15;16(4):562. Erratum in: Int J Environ Res Public Health [Internet] 2019 [consultado 20 Feb 2021]; 24;17(1). Disponible en: https://pubmed.ncbi.nlm.nih.gov/30781414/.
  34. López-Marin L, Chávez M, García O, Flores F, García Z, Herrera V, et al. Histopatología de la enfermedad renal crónica de etiología desconocida en comunidades agrícolas salvadoreñas. MEDICC Rev. 2014 16;49-54.
  35. Orantes-Navarro C, Almaguer-López, M, Alonso-Galbán, P, Díaz-Amaya M, Hernández S, Herrera-Valdés R, et al. The Chronic Kidney Disease Epidemic in El Salvador: a cross-sectional study. MEDICC Rev [Internet]. 2019 [consultado 21 Feb 2021]; 21;29-37. Disponible en: https://www.medigraphic.com/pdfs/medicreview/mrw-2019/mrw192_3g.pdf.
  36. Cortés-Genchi P, Villegas-Arrizén A, Aguilar-Madrid M, Paz-Román M, Maruris-Reducindo C, Mauris-Reducindo C, et al. Síntomas ocasionados por plaguicidas en trabajadores agrícolas. Rev. Med. Inst. Mex. Seguro Soc [Internet]. 2008 [consultado 21 Feb 2021]; 46;145-52. Disponible en: https://www.medigraphic.com/pdfs/imss/im-2008/im082f.pdf.
  37. Vela X, Henríquez, S, Zelaya S, Demy V, Hernández, M. Orantes, C. Enfermedad renal crónica y factores de riesgo asociados en dos comunidades agrícolas Salvadoreñas. MEDICC Rev [Internet]. 2014 [consultado 21 Feb 2021]; 16;55-60. Disponible en: https://www.medigraphic.com/pdfs/medicreview/mrw-2014/mrw142i.pdf.
  38. Orantes C, Herrera R, Almaguer M, Brizuela E, Nuñez l, Alvarado P, et al. Epidemiology of chronic kidney disease in adults of Salvadoran agricultural communities. MEDICC Rev [Internet]. 2014 [consultado 22 Feb 2021]; 16;23-30. Disponible en: https://www.medigraphic.com/pdfs/medicreview/mrw-2014/mrw142e.pdf.
  39. López, K, Pinedo, C, Zambrano, M Prácticas de Salud Ocupacional y niveles de biomarcadores séricos en aplicadores de plaguicidas de cultivos de arroz en Natagaima-Tolima, Colombia. Revista de Toxicología [Internet]. 2015 [Consultado 30 Abr 2021]; 32(2):102-6. Disponible en: https://www.redalyc.org/articulo.oa?id=91942717005.
  40. Schaeffer J, Adgate, J, Reynols S, Butler-Dowson J, Krisher, L, Dally M, et al. A Pilot Study to Assess Inhalation Exposures among Sugarcane Workers in Guatemala: Implications for Chronic Kidney Disease of Unknown Origin. Int J Environ Res Public Health [Internet]. 2020 [consultado 22 Feb 2021]; 7;17(16):5708. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7459472/.
  41. Bandiera S, Pulcinelli R, Huf F, Almeida F, Halmenschlager G, Bitencourt P, et al. Hepatic and renal damage by alcohol and cigarette smoking in rats. Toxicol Res [Internet]. 2020 [consultado 23 Feb 2021]; 13;37(2):209-19. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8007694/.
  42. Selmi S, Rtibi K, Grami D, Sebai H, Marzouki L. Malathion, an organophosphate insecticide, provokes metabolic, histopathologic and molecular disorders in liver and kidney in prepubertal male mice. Toxicol Rep [Internet]. 2018 [consultado 23 Feb 2021]; 9;5:189-95. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5977160/.
  43. Mesnage R, Matthew A, Constanzo M, Malatesta M, Séralini G, Antoniou M. Transcriptome profile analysis reflects rat liver and kidney damage following chronic ultra-low dose Roundup exposure. Environ. Health [Internet]. 2015 [consultado 23 Feb 2021]; 14; aprox. 1 p. Disponible en: https://pubmed.ncbi.nlm.nih.gov/28335822/.
  44. Xia Y, Li J, Ren W, Feng Z, Huang R, Yin Y. Transcriptomic analysis on responses of the liver and kidney of finishing pigs fed cadmium contaminated rice. J Sci Food Agric [Internet]. 2018 [consultado 24 Feb 2021]; 98(8):2964-72. Disponible en: https://pubmed.ncbi.nlm.nih.gov/29171875/.
  45. Wasana H, Perera G, Gunawardena P, Bandara J. WHO water quality standards Vs Synergic effect(s) of fluoride, heavy metals and hardness in drinking water on kidney tissues. Sci Rep [Internet]. 2017 [consultado 24 Feb 2021]; 7;42516. Disponible en: https://pubmed.ncbi.nlm.nih.gov/28195172/.

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