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Abstract
Introduction: The frailty syndrome in dialysis patients can deteriorate the health-related quality of life.
Objective: To analyze the association between frailty syndrome and health-related quality of life in patients undergoing continuous ambulatory peritoneal dialysis.
Materials and Methods: A descriptive cross-sectional study was conducted in Mexico City. The convenience sample included 106 patients from the peritoneal dialysis program, of which 62% were male. Age, marital status, occupation, education level, body mass index, creatinine, and albumin were recorded. Health-related quality of life was assessed using KDQOL SF-36 and frailty syndrome through the Short Physical Performance Battery (SPPB).
Results: SPPB scores showed a significant correlation with certain categories of KDQOL SF-36, such as kidney disease effects, kidney disease burden, and physical components. Gait speed test scores were not associated with any category of KDQOL SF-36. There were also no associations between the scores obtained in the mental component of KDQOL SF-36 and those of the SPPB tests. Health-related quality of life was lower in patients with frailty, advanced age, or hypoalbuminemia.
Conclusions: Patients undergoing peritoneal dialysis have a high prevalence of frailty syndrome and decreased quality of life. Furthermore, the high frailty rate is associated with poorer quality of life, especially in physical performance.
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Copyright (c) 2023 Melanie Christy Peralta-Flores, Mª Cristina Rodríguez-Zamora, Dante Amato, Anna Miriam Cabrera-Delgado
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References
- Paniagua-Sierra JR, Galván-Plata ME. Enfermedad renal crónica. Rev Med Inst Mex Seguro Soc 2017;55(2):116-7.
- Nixon AC, Bampouras TM, Pendleton N, Woywodt A, Mitra S, Dhaygude A. Frailty and chronic kidney disease: current evidence and continuing uncertainties. Clin Kidney J 2018;11(2):236-45. DOI: https://doi.org/10.1093/ckj/sfx134
- Nowicka M, Górska M, Edyko K, Szklarek-Kubicka M, Kazanek A, Prylinska M, et al. Association of physical performance, muscle strength, and body composition with self-assessed quality of life in hemodialyzed patients: a cross-sectional study. J Clin Med 2022;11:228. DOI: https://doi.org/10.3390/jcm11092283
- Matsuzawa R, Suzuki Y, Yamamoto S, Harada M, Watanabe T, Shimoda T, et al. Determinants of health-related quality of life and physical performance-based components of frailty in patients undergoing hemodialysis. J Ren Nut 2021;31(5):529-36. DOI: https://doi.org/10.1053/j.jrn.2020.08.011
- Guralnik JM, Simonsick EM, Ferrucci L, Glynn RJ, Berkman LF, Blazer DG, et al. A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission. J Gerontol 1994;49(2):M85-94. DOI: https://doi.org/10.1093/geronj/49.2.M85
- Pavasini R, Guralnik J, Brown JC, di Bari M, Cesari M, Landi F, et al. Short physical performance battery and all-cause mortality: systematic review and meta-analysis. BMC Medicine. 2016;14:215. DOI: https://doi.org/10.1186/s12916-016-0763-7
- Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, et al. Cardiovascular Health Study Collaborative Research Group. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci 2001;56(3):M146-56. DOI: https://doi.org/10.1093/gerona/56.3.M146
- Mansur HN, Colugnati FA, Grincenkov FR, Bastos MG. Frailty and quality of life: a cross sectional study of Brazilian patients with pre-dialysis chronic kidney disease. Health Qual Life Outcomes 2014;12:27. DOI: https://doi.org/10.1186/1477-7525-12-27
- Portilla-Franco ME, Tornero-Molina F, Gil-Gregorio P. Frailty in elderly people with chronic kidney disease. Nefrología 2016;36(6):609-15. DOI: https://doi.org/10.1016/j.nefroe.2016.12.005
- Paniagua R, Amato D, Vonesh E, Guo A, Mujais S. Health-related quality of life predicts outcomes but is not affected by peritoneal clearance: The ADEMEX trial. Kidney Int 2005;67(3):1093-104. DOI: https://doi.org/10.1111/j.1523-1755.2005.00175.x
- Roshanravan B, Khatri M, Robinson-Cohen C, Levin G, Patel KV, de Boer IH, Seliger S, Ruzinski J, Himmelfarb J, Kestenbaum B. A prospective study of frailty in nephrology-referred patients with CKD. Am J Kidney Dis 2012; 60(6):912-21. DOI: https://doi.org/10.1053/j.ajkd.2012.05.017
- Lee SJ, Son H, Shin SK. Influence of frailty on health-related quality of life in pre-dialysis patients with chronic kidney disease in Korea: a cross sectional study. Health Qual Life Outcomes 2015;13:70. DOI: https://doi.org/10.1186/s12955-015-0270-0
- Zugasti-Murillo A, Casas-Herrero A. Síndrome de fragilidad y estado nutricional: valoración, prevención y tratamiento. Nutr Hosp 2019;36(2):26-37. DOI: https://doi.org/10.20960/nh.02678
- Cabrera-Delgado AM, Rodríguez-Zamora MC, Ventura-García MJ, Santillán-Torres C, Amato D. Asociación de estrategias de afrontamiento y calidad de vida relacionada con la salud en pacientes en diálisis peritoneal. Enferm Nefrol 2019;22(4):398-404. DOI: https://doi.org/10.4321/S2254-28842019000400006
- Kim JY, Kim B, Park KS, Choi JY, Seo JJ, Park SH, et al. Health related quality of life with KDQOL-36 and its association with self-efficacy and treatment satisfaction in Korean dialysis patients. Qual Life Res 2013;22(4):753-8. DOI: https://doi.org/10.1007/s11136-012-0203-x
- McAdams-DeMarco MA, Ying H, Olorundare I, King EA, Desai N, Dagher N, Lonze B, Montgomery R, Walston J, Segev DL. Frailty and health-related quality of life in end stage renal disease patients of all ages. J Frailty Aging 2016;5(3):174-9. DOI: https://doi.org/10.14283/jfa.2016.106
- Cobacho-Salmoral O, Parra-Martos L, Laguna-Castro M, Crespo-Montero R. Factores asociados a la fragilidad en el paciente en tratamiento renal sustitutivo con diálisis. Una revisión sistemática. Enferm Nefrol 2021;24(3):233-48. DOI: https://doi.org/10.37551/S2254-28842021021
References
Paniagua-Sierra JR, Galván-Plata ME. Enfermedad renal crónica. Rev Med Inst Mex Seguro Soc 2017;55(2):116-7.
Nixon AC, Bampouras TM, Pendleton N, Woywodt A, Mitra S, Dhaygude A. Frailty and chronic kidney disease: current evidence and continuing uncertainties. Clin Kidney J 2018;11(2):236-45. DOI: https://doi.org/10.1093/ckj/sfx134
Nowicka M, Górska M, Edyko K, Szklarek-Kubicka M, Kazanek A, Prylinska M, et al. Association of physical performance, muscle strength, and body composition with self-assessed quality of life in hemodialyzed patients: a cross-sectional study. J Clin Med 2022;11:228. DOI: https://doi.org/10.3390/jcm11092283
Matsuzawa R, Suzuki Y, Yamamoto S, Harada M, Watanabe T, Shimoda T, et al. Determinants of health-related quality of life and physical performance-based components of frailty in patients undergoing hemodialysis. J Ren Nut 2021;31(5):529-36. DOI: https://doi.org/10.1053/j.jrn.2020.08.011
Guralnik JM, Simonsick EM, Ferrucci L, Glynn RJ, Berkman LF, Blazer DG, et al. A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission. J Gerontol 1994;49(2):M85-94. DOI: https://doi.org/10.1093/geronj/49.2.M85
Pavasini R, Guralnik J, Brown JC, di Bari M, Cesari M, Landi F, et al. Short physical performance battery and all-cause mortality: systematic review and meta-analysis. BMC Medicine. 2016;14:215. DOI: https://doi.org/10.1186/s12916-016-0763-7
Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, et al. Cardiovascular Health Study Collaborative Research Group. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci 2001;56(3):M146-56. DOI: https://doi.org/10.1093/gerona/56.3.M146
Mansur HN, Colugnati FA, Grincenkov FR, Bastos MG. Frailty and quality of life: a cross sectional study of Brazilian patients with pre-dialysis chronic kidney disease. Health Qual Life Outcomes 2014;12:27. DOI: https://doi.org/10.1186/1477-7525-12-27
Portilla-Franco ME, Tornero-Molina F, Gil-Gregorio P. Frailty in elderly people with chronic kidney disease. Nefrología 2016;36(6):609-15. DOI: https://doi.org/10.1016/j.nefroe.2016.12.005
Paniagua R, Amato D, Vonesh E, Guo A, Mujais S. Health-related quality of life predicts outcomes but is not affected by peritoneal clearance: The ADEMEX trial. Kidney Int 2005;67(3):1093-104. DOI: https://doi.org/10.1111/j.1523-1755.2005.00175.x
Roshanravan B, Khatri M, Robinson-Cohen C, Levin G, Patel KV, de Boer IH, Seliger S, Ruzinski J, Himmelfarb J, Kestenbaum B. A prospective study of frailty in nephrology-referred patients with CKD. Am J Kidney Dis 2012; 60(6):912-21. DOI: https://doi.org/10.1053/j.ajkd.2012.05.017
Lee SJ, Son H, Shin SK. Influence of frailty on health-related quality of life in pre-dialysis patients with chronic kidney disease in Korea: a cross sectional study. Health Qual Life Outcomes 2015;13:70. DOI: https://doi.org/10.1186/s12955-015-0270-0
Zugasti-Murillo A, Casas-Herrero A. Síndrome de fragilidad y estado nutricional: valoración, prevención y tratamiento. Nutr Hosp 2019;36(2):26-37. DOI: https://doi.org/10.20960/nh.02678
Cabrera-Delgado AM, Rodríguez-Zamora MC, Ventura-García MJ, Santillán-Torres C, Amato D. Asociación de estrategias de afrontamiento y calidad de vida relacionada con la salud en pacientes en diálisis peritoneal. Enferm Nefrol 2019;22(4):398-404. DOI: https://doi.org/10.4321/S2254-28842019000400006
Kim JY, Kim B, Park KS, Choi JY, Seo JJ, Park SH, et al. Health related quality of life with KDQOL-36 and its association with self-efficacy and treatment satisfaction in Korean dialysis patients. Qual Life Res 2013;22(4):753-8. DOI: https://doi.org/10.1007/s11136-012-0203-x
McAdams-DeMarco MA, Ying H, Olorundare I, King EA, Desai N, Dagher N, Lonze B, Montgomery R, Walston J, Segev DL. Frailty and health-related quality of life in end stage renal disease patients of all ages. J Frailty Aging 2016;5(3):174-9. DOI: https://doi.org/10.14283/jfa.2016.106
Cobacho-Salmoral O, Parra-Martos L, Laguna-Castro M, Crespo-Montero R. Factores asociados a la fragilidad en el paciente en tratamiento renal sustitutivo con diálisis. Una revisión sistemática. Enferm Nefrol 2021;24(3):233-48. DOI: https://doi.org/10.37551/S2254-28842021021