Estudio de la eficacia del sellado con taurolidina y citrato 4% del catéter

Abstract

The use of central catheters has increased signifi cantly despite their greater morbi-mortality compared to AVF. The main complications are thrombosis, bacteriaemiasepsis, and limitation of dialysis effi cacy, reducing quality of life for patients and increasing the healthcare cost. In our unit, 5% heparin sodium was previously used as lock solution and we currently use TauroLock™-Hep 500®, composed of (cyclo)-taurolidine (biocompatible antimicrobial agent) 4% citrate and heparin 500 UI/ml . Objective: To verify the effi cacy of Taurolock in reducing the incidence of intraluminal colonization and thrombosis compared with 5% heparin sodium. Material and method: We carried out a longitudinal observational cohort study and we analysed intraluminal colonization, thrombosis, biofi lm and use of antibiotherapy. Results: We observed an improvement in catheter permeability, a reduction in the use of urokinase, reduction in unipuncture sessions and in use of antibiotic. Conclusions: Our study shows that using a lock solution that contains taurolidine as an antimicrobial agent for haemodialysis catheters can signifi cantly reduce the incidence of catheter-related sepsis. Taurolidine appears to be effective and safe and does not entail risks or side effects. The addition of 500 iu of heparin to the lock solution together with 4% citrate has reduced thrombotic events by reducing the use of fi brilolytics and elimina ting completely the use of unipuncture, presenting an improvement in dialysis efficacy.