Hepatitis tóxica inducida por fármacos en un paciente con diálisis peritoneal

Abstract

Peritonitis is the main complication in peritoneal dialysis (PD) and requires early empirical antibiotic treatment which often includes the use of vancomycin with the liver being the organ involved in the transformation of most drugs which can lead to liver toxicity¹. Although infectious hepatitis is the most common, it can also be caused by the metabolisation of some drugs. Antibiotics are a widely used group of medicines, but adverse hepatotoxic effects should be considered rare given the very wide variety of this drug prescription. Hepatotoxic reactions to certain antibiotics can help professionals to identify early causes of hepatotoxicity, most of which are idiosyncratic, with a history of allergy at times, and therefore cannot be predicted. The importance of antimicrobial-induced hepatotoxicity lies in the severe morbidity and mortality of the condition². Among the unpredictable liver toxicants is vancomycin¹. We consider this case because of the frequency with which vancomycin is used in PD.