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Abstract
Fragility can be defined as a physiological state of increased vulnerability to stress factors, resulting from the depletion of physiological reserves or the deregulation of multiple physiological systems1. The predominant view is that a physiological decline, associated with disease or age, which individually does not reach clinical significance, as it affects multiple systems and has a cumulative character, can be detected as fragility2. Fragility is pointed out by different authors as a strong predictor of disability, hospitalization, falls, loss of mobility and cardiovascular disease3, with fragile individuals being more vulnerable to adverse events2.
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